An Unbiased View of Phentermine For Weight Loss - Mayo Clinic thumbnail

An Unbiased View of Phentermine For Weight Loss - Mayo Clinic

Published Apr 12, 22
10 min read

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More serious problems such as elevated blood pressure, dizziness, heart palpitations, shortness of breath, tremors, and chest pain can also occur. Am I a candidate for ADIPEX? ADIPEX and other weight-loss medications are intended for people who are obese or have health problems related to being overweight, such as diabetes, high blood pressure, or high cholesterol.

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Obesity is having a BMI of 30 or higher. People who have a BMI between 25 and 30 are classified as overweight. After considering your BMI, medical history, and current medications, the Nuvida, Rx team determines whether you’re an appropriate candidate for ADIPEX. Since ADIPEX is a stimulant, it can increase your heart rate.

It is indicated for people who are obese, and who have failed to lose enough weight with diet and exercise alone — not for people who want to lose just a few pounds. Phentermine is a Schedule IV drug, a classification given to drugs that have a potential for abuse, although the actual potential appears to be low.

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Supplemental Materials for Effects of low-dose, controlled-release,  phentermine plus topiramate combination on weight and associated  comorbidities in overweight and obese adults (CONQUER): a randomised,  placebo-controlled, phase 3 trial - The LancetPhentermine - Wikipedia


Most people want to lose weight, either for health, fitness, or aesthetic reasons. Weight loss can be frustrating, especially when you’re doing everything right but still hit a plateau and the scale refuses to budge. Phentermine is a weight-loss drug, developed in the 1950s, that has been incredibly popular as the go-to weight loss aid.

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Who Is This Product Best For? While anyone can benefit from these weight loss pills, they’re best for people looking to lose that final bit of fat and finally achieve their ideal physique. The manufacturers of Prime, Shred have enough faith in their product to offer a 100-day money-back guarantee.

Some people experience such a strong effect that they even forget to eat, which is one of the reasons why phentermine can be extremely dangerous. Doctors formerly recommended phentermine diet pills to patients with a dangerous body mass index due to its reputation as a potent appetite suppressant and metabolism booster.

The U.S. Food and Drug Administration warns doctors that “The limited usefulness of [this substance] should be measured against possible risk factors inherent in their use.”The rise of other prescription medications and interventions has led to a massive decline of phentermine prescriptions, and even today, doctors only prescribe its use under strict medical supervision.

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As many of these OTC phentermine alternatives are supplements and not FDA-approved weight loss medications, finding effective and reputable diet pills can be a huge challenge. We used a set of four criteria when we looked at various diet pills to determine whether they might be worth your time and money.

When looking for the best natural phentermine alternative, we looked at the ingredient combination as well as the dosages of the various ingredients. Most diet pills use a combination of ingredients to tackle weight loss in various ways. Many compounds have synergistic effects, meaning they’re more effective when used together.

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The dose of an active ingredient is just as important as the ingredient itself. In most cases, the more of an active ingredient you get, the better the final result. However, be careful with stimulants like caffeine - some people have lower tolerances, and a high-caffeine OTC phentermine alternative may make you feel jittery and sick.

ReviewsLooking at reviews is a good way to estimate the potential effectiveness of a particular weight loss supplement. Make sure to look at trends since there will always be individual outliers that have either a great or very poor experience with any product. When it comes to any phentermine over-the-counter diet pill, remember that diet and exercise play an important role in the end result.

Price and Guarantee, Unlike FDA-regulated prescription medication, most diet pills are unregulated and untested. Plenty of unscrupulous manufacturers will lie about their miracle diet pill and fail to include any active ingredients in their products to keep costs low. Often, a very cheap diet pill will contain nothing but filler.

Does Phentermine Work for Weight Loss? Yes, it works very well. Unfortunately, the side effects of using the drug can be very severe, and doctors will only recommend it in individuals with serious weight and health concerns and only on a very short-term basis. While alternatives may not have the same level of effectiveness, they are much safer and are still effective enough to be worth your time.

The ones we’ve reviewed tend to cost around $60 for a month’s supply. However, most companies will have specials to enable you to get significant discounts if you order multiple products at once. Some of the most cost-effective choices are any “buy three months and get two months free” promotions, which can save you almost 50% on the price of an individual bottle.

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But such programs don’t work for up to one in three patients. And weight regain is common after 6 months, the point when such programs can yield weight loss of 5 percent to 10 percent. Weight-loss medications are one way to help more people to have larger, and potentially longer lasting, responses to lifestyle interventions, as placebo-controlled trials have shown.

And anecdotal reports from many of my colleagues suggested that it was helpful for many patients long-term. But there’s a lack of research on its longer-term safety and efficacy. Phentermine is available as an inexpensive generic medication, but concerns have been raised about addiction and, because of how it acts, cardiovascular side effects.

The 144 people who used phentermine continuously for more than a year had kept off more than 7 percent of their baseline weight at 2 years. It’s important to monitor patients for their response to phentermine treatment. About a third of people prescribed phentermine lost less than 3 percent of their weight within the first 3 months of starting the drug.

By contrast, people who had an early response to the medication — losing at least 3 percent of their weight by 3 months — tended to have greater overall long-term success at weight loss with the aid of the medication. As far as safety goes, we expected to see an increase in blood pressure, but instead found that systolic blood pressure was reduced at 24 months in long-term users of phentermine relative to short-term users.



Similar to what we have seen in studies of the combination medication Qsymia, it appears that some patients can safely maintain long-term weight loss with phentermine alone. Still, until we have a change in FDA policy, off-label longer-term prescribing of phentermine should be done cautiously with full consideration of the legal and medical licensure implications, which can vary from state to state.

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Eating a well-balanced, reduced-calorie diet and exercising regularly are the cornerstones of weight loss, but certain drugs can provide powerful support. One such drug is phentermine — one of the most popular weight loss drugs in the world. It has been proven effective for short-term weight loss when used alongside a reduced-calorie diet and exercise.

To put this into perspective, a 5–7% weight loss is 10–14 pounds (4. 5–6. 4 kg) for a person who weighs 200 pounds (90. 7 kg). However, not everyone responds the same way to this medication. If you haven’t lost much weight after 3 months of using it, a healthcare professional may recommend discontinuing the medication.

While phentermine has been shown to be effective for weight loss, it may work better when combined with topiramate. Topiramate is a drug that has been used on its own to treat seizures but, like phentermine, also has appetite-reducing properties (, , ). Topiramate and phentermine is a combination medication sold under the brand name Qsymia.

Compared to three other commonly prescribed drugs for weight loss, the combination of phentermine and topiramate was associated with the highest odds of losing at least 5% of initial body weight (). What’s more, a recent analysis of studies found that people who took a medication that combined phentermine and topiramate lost 16 pounds (7.

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In another 12-week study, people with BED or bulimia nervosa received the drug combination or a placebo (). Over 28 days, treatment with the phentermine and topiramate combination decreased the participants’ number of binge-eating days from 16. 2 to 4. 2. The same results were not observed in the placebo group ().

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To prevent insomnia or difficulty falling or staying asleep, you should avoid taking the last dose too late in the day. Phentermine and topiramate, The combination of phentermine and topiramate — sold under the brand name Qsymia — is a medication used for weight loss. This medication is available in four doses, ranging in strength from 3.

It’s offered in an extended-release capsule that should be taken in the morning (, , ). After you take the lowest dose for 14 days, your doctor can choose to progress you to a higher dose (, ). According to the FDA, you should stop using the medication if you don’t lose 3% of your body weight after 12 weeks on the highest daily dose ().

Phentermine alone is designed for short-term use only, as there are few long-term studies on its safety. One study observed that people experienced no significant side effects when they took phentermine for up to 24 months (). However, the FDA has approved phentermine in combination with topiramate for long-term use, since the doses of the two ingredients are lower than the maximum doses of the individual drugs ().

While some common side effects are associated with the use of phentermine and topiramate, most people tolerate it. However, people who have certain conditions or are pregnant or nursing should not use phentermine and topiramate. Most often, healthcare professionals prescribe phentermine and topiramate after you’ve tried other lifestyle modifications for weight loss but haven’t seen significant results.

For these reasons, a healthcare professional will likely recommend that you make healthy lifestyle changes before recommending a weight loss medication. Some examples of healthy lifestyle changes you can make include (, , ): If you have excess weight to lose, you can try to eat 300–500 fewer calories per day.

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This will help promote long-term, sustainable results. Lifestyle and behavior modifications are the cornerstones of successful weight loss and maintenance. Phentermine is a prescription-only appetite suppressant and weight loss pill approved for short-term use. The combination of phentermine and topiramate appears to be even more effective than phentermine alone, and it’s approved for long-term use.